SOCS1 methylation level is associated with prognosis in patients with acute-on-chronic hepatitis B liver failureArticle Published on 2023-05-062023-06-12 Journal: Clinical Epigenetics [Category] B형 간염, Fulltext, [키워드] Acute-on-chronic hepatitis B liver failure DNA methylation glucocorticoid MethyLight Prognosis SOCS1. [DOI] 10.1186/s13148-023-01495-9 PMC 바로가기
Sex-biased expression of the TLR7 gene in severe COVID-19 patients: Insights from transcriptomics and epigenomicsArticle Published on 2022-12-012022-11-16 Journal: Environmental research [Category] 유전자 메커니즘, [키워드] acute phase analyzed Blood Cohort coronavirus disease COVID-19 COVID-19 patient CpG DNA DNA methylation dose downregulated embryogenesis epidemiological data epigenomic epigenomics Evidence expression female females gene product Genetic variation Genome-wide association studies Host inactivation incidence incidence of COVID-19 independent insight long-COVID-19 male males Methylation n-Counter. nasal patients Post-infection RNAseq Saliva Severe case severe COVID-19 severity Sex significantly higher stratified suggested timepoint TLR7 TLR7 gene transcriptomics with COVID-19 [DOI] 10.1016/j.envres.2022.114288 PMC 바로가기
DNA methylation profiles in pneumonia patients reflect changes in cell types and pneumonia severityArticle Published on 2022-12-012023-07-08 Journal: Epigenetics [Category] COVID19(2023년), [키워드] Biomarkers cell-type deconvolution DNA methylation Pneumonia SARS-CoV-2 targeted bisulfite sequencing. [DOI] 10.1080/15592294.2022.2051862 PMC 바로가기
Epigenetic rewiring of pathways related to odour perception in immune cells exposed to SARS-CoV-2 in vivo and in vitroArticle Published on 2022-12-012023-07-09 Journal: Epigenetics [Category] COVID19(2023년), [키워드] DNA methylation in vitro stimulation interactome Mild-to-moderate module identification network analysis. PBMC SARS-CoV-2 [DOI] 10.1080/15592294.2022.2089471 PMC 바로가기
A machine learning approach utilizing DNA methylation as an accurate classifier of COVID-19 disease severityArticle Published on 2022-10-192022-11-16 Journal: Scientific Reports [Category] 변종, [키워드] applied approach average benefit Classifier Cohort COVID-19 COVID-19 disease COVID-19 disease severity COVID-19 pandemic dataset DNA methylation Epigenetic external validation Gene Expression Omnibus identify increased risk individual logit Methylation methylation site NCBI non-infected outcome pathology platform Pneumonia processed produced provide random forest classification Receiver operator characteristic severe COVID-19 disease Therapies unique utility Vaccine variant [DOI] 10.1038/s41598-022-22201-4 PMC 바로가기
HLA-C dysregulation as a possible mechanism of immune evasion in SARS-CoV-2 and other RNA-virus infectionsArticle Published on 2022-10-172022-11-16 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] alteration Analysis antigenic Cell cells changes in co-morbidities COVID-19 COVID-19 patient COVID-19 patients decrease DNA DNA methylation dysregulation enhancer enhancer transcriptional regulation evade expression Gene Expression gene expression profile genes encoding healthy controls HLA-C Host immune evasion immune response immune system implicated Infection inhibit Intervention involved mechanism memory response Methylation modify overlap Pathogens presenting Prognosis Prognostic marker Protein respiratory infection SARS-CoV-2 shown significantly symptomatic and asymptomatic symptomatic and asymptomatic COVID-19 T-cell therapeutic target transcriptional upper airway upper airways cells. viral antigens virus [DOI] 10.3389/fimmu.2022.1011829 PMC 바로가기
Epigenetic mechanisms and host factors impact ACE2 gene expression: Implications in COVID-19 susceptibilityResearch article Published on 2022-10-012022-10-05 Journal: Infection, genetics and evolution : journal of mol [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] ACE2 gene ACE2 protein age angiotensin-converting enzyme 2 Arterial hypertension association Asthma BMI body mass index changes in clinical variable clinical variables COVID-19 COVID-19 susceptibility described determinant disease susceptibility DNA methylation Epigenetic epigenetics evaluate evaluated expression expression profile Factor Host host cell host factors Infection involved Male sex mechanism Methylation molecular cause mRNA expression nasopharyngeal swab sample obesity overexpression Peripheral blood promoter region quantified regulated Result risk factor RT-qPCR SARS-CoV-2 SARS-COV-2 infection Sex significant difference smoking study group susceptibility the disease type II diabete underlying disease Variability variable virus volunteers was determined [DOI] 10.1016/j.meegid.2022.105357 [Article Type] Research article
The human EF1a promoter does not provide expression of the transgene in miceArticle Published on 2022-10-012023-07-10 Journal: Transgenic Research [Category] COVID19(2023년), [키워드] DNA methylation EF1a promoter expression Pronuclear microinjection Transgenesis. [DOI] 10.1007/s11248-022-00319-5 PMC 바로가기
Understanding the epigenetic mechanisms in SARS CoV-2 infection and potential therapeutic approachesSARS CoV-2 감염의 후성유전학적 기전과 잠재적인 치료적 접근의 이해Review Published on 2022-09-012022-09-11 Journal: Virus research [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus Anti-viral immune response association build caused Community coronavirus COVID-19 disease severity DNA DNA methylation drug effective eliminating Epigenetic epigenetic regulator epigenetics Escalation Health highlight histone Histone modification host cell host cells immune immune responses Immunity Infection initial Interaction mechanism microRNA Modification Mortality pandemic Pathogenesis pathogenesis of SARS-CoV-2 reduced risk SARS CoV-2 SARS- CoV-2 SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infection. severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 severity subsequent the disease therapeutic approach therapeutic intervention Therapies understanding variants of SARS-CoV-2 viral infection Virology [DOI] 10.1016/j.virusres.2022.198853 PMC 바로가기 [Article Type] Review
Epigenetic activation of antiviral sensors and effectors of interferon response pathways during SARS-CoV-2 infectionArticle Published on 2022-09-012022-11-15 Journal: Biomedicine & pharmacotherapy = Biomédecine & phar [Category] COVID19(2023년), SARS, 바이오마커, 진단, [키워드] Activation Affect Antiviral Biomarker blood cell change changes in Cohort coronavirus COVID-19 COVID-19 disease COVID-19 patient COVID-19 patients DNA DNA methylation effector Epigenetic epigenetics expression expression of gene Hospitalized identify Infection intensive care unit Interaction interferon response involved lesion management Methylation MOST outcomes pathology pathophysiology pathway Patient populations Potential treatment recent reported SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2. Severity of infection shown subset Symptom Symptoms the disease transcriptomics upper respiratory tract [DOI] 10.1016/j.biopha.2022.113396 PMC 바로가기